MAP 30: a new inhibitor of HIV-1 infection and replication
S Lee-Huang, PL Huang, PL Nara, HC Chen, H Kung… - FEBS letters, 1990 - Elsevier
A new inhibitor of human immunodeficiency virus (HIV) has been isolated and purified to
homogeneity from the seeds and fruits of the Momordica charantia. This compound, MAP 30
(Momordica Anti-HIV Protein), is a basic protein of about 30 kDa. It exhibits dose-dependent
inhibition of cell-free HIV-1 infection and replication as measured by:(i) quantitative focal
syncytium formation on CEM-ss monolayers;(II) viral core protein p24 expression; and (iii)
viral-associated reverse transcriptase (RT) activity in HIV-1 infected H9 cells. The doses …
homogeneity from the seeds and fruits of the Momordica charantia. This compound, MAP 30
(Momordica Anti-HIV Protein), is a basic protein of about 30 kDa. It exhibits dose-dependent
inhibition of cell-free HIV-1 infection and replication as measured by:(i) quantitative focal
syncytium formation on CEM-ss monolayers;(II) viral core protein p24 expression; and (iii)
viral-associated reverse transcriptase (RT) activity in HIV-1 infected H9 cells. The doses …
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